反应详情

To a solution of 877 mg of 5-(2-bromoacetyl)-2-methoxycarbonylfuran in 40 ml of methanol was added 800 mg of 4-methoxy-3-propoxythiobenzamide, and the mixture was refluxed for 1 hour. The reaction mixture was concentrated approximately ¼, then added diethyl ether. After cooling the solution, a precipitate was collected by filtration and dried to obtain 1.05 g of 2-(4-methoxy-3-propoxyphenyl)-4-(5-methoxycarbonyl-2-furyl)thiazole as a brown powder. mp. 141.0-142.0° C.

1. temperaturethe mixture was refluxed for 1 hour
2. concentrationThe reaction mixture was concentrated approximately ¼
3. temperatureAfter cooling the solution
4. filtrationa precipitate was collected by filtration
5. customdried