HuagongsheHuagongshe Chemistry Print Report · For research reference only
Epichlorohydrin → 4-(2-Oxiranylmethoxy)benzenecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Cyanophenol | HCID 13019 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(2-Oxiranylmethoxy)benzenecarbonitrile | HCID 2764301 | 75% |
Reaction Steps
Epichlorohydrin (800 mL) and K2CO3 (414 g) were added to a stirred solution of p-cyanophenol (238 g) in 2.0 L MeCN and the reaction mixture was refluxed under inert atmosphere for 2 h. The hot solution was filtered and the filtrate concentrated giving a clear oil which was crystallized from di-iso-propyl ether giving the product in 75% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06291475B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-485c2deb0ca3474a8ce6e84eb85a1d67 |
| Source note | uspto-grants-2001_09 |