3-Nitrobenzenesulfonyl chloride → (Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonate

Participants

Reaction Conditions

Reaction Steps

m-Nitrobenzensulfonylchloride (12.6 g; 57 mmol) was added to a cold (−20° C.) solution of (R)-(+)-glycidol (5.5 g; 74 mmol) and TEA (10.3 mL; 74 mmol). The reaction mixture was stirred at −20° C. for 96 h. The solution was filtered and the filtrate washed with tartaric acid (10% w/w), brine, H2O and concentrated giving the title compound in a 97% yield.

Provenance & Evidence