HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Salicylate → Methyl 5-bromosalicylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Salicylate | HCID 4133 | — |
| Reactant | Bromine | HCID 24408 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Methyl 5-bromosalicylate | HCID 77683 | 83% |
Reaction Steps
Br2 (52 g) was slowly added to a stirred solution of methyl salicylate (50 g; 330 mmol) in 300 mL acetic acid. The reaction mixture was stirred at rt. for 10 h, poured on ice-water and the precipitate recrystallized from MeOH, giving the sub-title compound in a 83% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06291475B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-4723fe0e3a0c486c88a0b3ec071a587b |
| Source note | uspto-grants-2001_09 |