Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Methyl 5-cyano-2-hydroxybenzoate | HCID 10583428 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 21701954 | HCID 21701954 | — |
Reaction Steps
Cyclopropyl amine (14.3 g) and Na (100 mg) were added to a solution of methyl 5-cyano-2-hydroxybenzoate (10.0 g; from step (b) above) in DMSO (40 mL). The reaction mixture was heated at 80° C. in a sealed steel vessel overnight, diluted with H2O, acidified and extracted with EtOAc giving the sub-title compound (11.0 g), after concentration of the organic layer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06291475B1 |
|---|
| Source dataset | uspto-grants-2001_09 |
|---|
| ORD ID | ord-c741ba9118614520b62e5b2d31c9808d |
|---|
| Source note | uspto-grants-2001_09 |
|---|
