HCID 21701941, compound → HCID 57262422, compound

HRID 1596443Notes

Reaction equation

HRID 1596443 reaction equation
[OH:1][CH:2]([CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([N+:28]([O-])=O)=[CH:24][CH:23]=1)[CH2:3][N:4]1[CH2:11][CH:10]2[CH2:12][CH:6]([CH2:7][N:8]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9]2)[CH2:5]1>CCO.[Pd]>[NH2:28][C:25]1[CH:24]=[CH:23][C:22]([O:21][CH2:20][CH:2]([OH:1])[CH2:3][N:4]2[CH2:11][CH:10]3[CH2:12][CH:6]([CH2:7][N:8]([C:13]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:14])[CH2:9]3)[CH2:5]2)=[CH:27][CH:26]=1

Participants

4

Reactant 1

HCID 21701941HCID 21701941, compound

Product 1

HCID 57262422HCID 57262422, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The title compound was prepared quantitatively from tert-butyl 7-[2-hydroxy-3-(4-nitrophenoxy)propyl]-3,7-diazabicyclo[3.3.1 ]nonane-3-carboxylate (see Example 12 above) using catalytic hydrogenation on 5% Pd/C in EtOH at 1 atm.

Sources & evidence

ORD record
ord-2aadc6429bb1406c8d9607d756cd93ce
Source dataset
uspto-grants-2001_09
Patent number
US06291475B1

Reaction notes

Loading…