4-(Oxiran-2-yl)benzonitrile → HCID 54549064, compound

HRID 1596455Notes

Reaction equation

HRID 1596455 reaction equation
[O:1]1[CH2:3][CH:2]1[C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=1.[CH:12]12[CH2:20][CH:16]([CH2:17][NH:18][CH2:19]1)[CH2:15][N:14]([C:21]([O:23][CH:24]([CH3:26])[CH3:25])=[O:22])[CH2:13]2>>[C:8]([C:7]1[CH:10]=[CH:11][C:4]([CH:2]([OH:1])[CH2:3][N:18]2[CH2:19][CH:12]3[CH2:20][CH:16]([CH2:15][N:14]([C:21]([O:23][CH:24]([CH3:26])[CH3:25])=[O:22])[CH2:13]3)[CH2:17]2)=[CH:5][CH:6]=1)#[N:9]

Participants

3

Reactant 2

HCID 404944-(Oxiran-2-yl)benzonitrileHCID 53914229HCID 53914229, compound

Product 1

HCID 54549064HCID 54549064, compound

Procedure

The crude reaction mixture from step (a) above was condensed with iso-propyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (5.2 g; see Example H above) according to the method described in Example 7 above to give the title compound in a 73% overall yield.

Sources & evidence

ORD record
ord-063a6aa724924865be2546de8545a5fa
Source dataset
uspto-grants-2001_09
Patent number
US06291475B1

Reaction notes

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