Tetrahydropyran-2-methanol → HCID 15888332, compound

Participants

Role	Name	HCID	Charge
Reactant	Tetrahydropyran-2-methanol	HCID 7524	—
Reactant	Triphenylphosphine	HCID 11776	—
Reactant	ethyl N-ethoxycarbonyliminocarbamate	HCID 220568	—
Reactant	2-(4-Methoxyphenyl)-3-(4-Hydroxybenzoyl)-6-Methoxybenzo[b]thiophene	HCID 9865197	—
Product	HCID 15888332	HCID 15888332	—

Reaction Steps

[6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-hydroxyphenyl)methanone (0.39 g, 1.00 mmol) and 2-hydroxymethyltetrahydropyran (174 mg, 1.5 mmol) were converted to the title compound by the procedure of Example 1 using 390 mg (1.5 mmol) of triphenylphosphine and 0.24 mL (1.5 mmol) of diethyl azodicarboxylate the only difference being that the total reaction time was 3 hours giving a thick syrup.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06291484B1
Source dataset	uspto-grants-2001_09
ORD ID	ord-e0c7058e030b428dab38b543abb74ffb
Source note	uspto-grants-2001_09