HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofurfuryl alcohol → HCID 15888334, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofurfuryl alcohol | HCID 7360 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | 2-(4-Methoxyphenyl)-3-(4-Hydroxybenzoyl)-6-Methoxybenzo[b]thiophene | HCID 9865197 | — |
| Product | HCID 15888334 | HCID 15888334 | 62.6% |
Reaction Steps
[6-Methoxy-2-(4-methoxyphenyl)benzo [b]thiophen-3-yl](4-hydroxyphenyl)methanone (390 mg, 1 mmol) and 2-hydroxymethyl tetrahydrofuran (153 mg, 1.50 mmol) were converted to 297 mg of the title compound by the procedure of Example 9 using 393 mg (31.5 mmol) of triphenylphosphine and 0.24 mL (1.5 mmol) of diethyl azodicarboxylate the only differences being that the chromatography eluent was 3:7 ethyl acetate:hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06291484B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-6642197a95c040649e26931fb702163d |
| Source note | uspto-grants-2001_09 |