Ethanethiol → HCID 15888351, compound

HRID 1596493Notes

Reaction equation

HRID 1596493 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]([OH:30])[CH2:22][N:23]4[CH2:28][CH2:27][CH2:26][CH:25]([CH3:29])[CH2:24]4)=[CH:15][CH:14]=3)=[O:12])=[C:9]([C:31]3[CH:36]=[CH:35][C:34]([O:37]C)=[CH:33][CH:32]=3)[S:8][C:7]=2[CH:39]=1.C(S)C.[Cl-].[Al+3].[Cl-].[Cl-]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH:21]([OH:30])[CH2:22][N:23]4[CH2:28][CH2:27][CH2:26][CH:25]([CH3:29])[CH2:24]4)=[CH:17][CH:18]=3)=[O:12])=[C:9]([C:31]3[CH:32]=[CH:33][C:34]([OH:37])=[CH:35][CH:36]=3)[S:8][C:7]=2[CH:39]=1

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 6451240Aluminum(III) ChlorideHCID 15888350HCID 15888350, compound

Product 1

HCID 15888351HCID 15888351, compoundYield 66%

Procedure

[6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-(2-hydroxy-3-[3-methylpiperidinyl]propoxy)phenyl]methanone (540 mg, 1.0 mmol) was converted to 340 mg of the title compound by the procedure of Example 32 using 360 mg (4.9 mmol) of ethanethiol and aluminum chloride.

Sources & evidence

ORD record
ord-270484746a3c4551b1b68ba17dd0073b
Source dataset
uspto-grants-2001_09
Patent number
US06291484B1

Reaction notes

Loading…