Lithium iodide → HCID 9820917, compound

Participants

Reaction Steps

Ethyl 1-(3,4-dichlorobenzenesulfonyl)-4,5,6,7-tetrahydroindole -2-carboxylate (66 mg) from Example 2d above and lithium iodide (228 mg) were dissolved in pyridine (5 ml) and heated at reflux for 5 hours, cooled, then concentrated in vacuo. The residue was partitioned between 2N HCl and ether. Combined organic extracts were dried (MgSO4), concentrated, and the residue triturated with ether to give the product as a white crystalline solid which was filtered and dried (18 mg, 28%), NMR d(DMSO) 1.65 (4H, m), 2.38 (2H, m), 2.80 (2H, m), 6.70 (1H, s), 7.90 (2H, m), 8.30 (1H, s); M/z (+) 373 (M-H+).

Provenance & Evidence