Stannous Chloride → Ethyl 3-(3-aminophenyl)3-benzoylamino-propionate

HRID 1596566Notes

Reaction equation

HRID 1596566 reaction equation
[C:1]([NH:9][CH:10]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-])=O)[CH:18]=1)[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Sn](Cl)Cl>>[NH2:23][C:19]1[CH:18]=[C:17]([CH:10]([NH:9][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 24479Stannous ChlorideHCID 3816281Ethyl 3-benzoylamino-3-(3-nitrophenyl)-propionate

Product 1

HCID 18505414Ethyl 3-(3-aminophenyl)3-benzoylamino-propionate

Procedure

Corresponding to Example 3b, 3 g of (4a) were reduced using tin-(II) dichloride. A white solid was obtained (yield: 2.6 g).

Workup

  1. customA white solid was obtained (yield: 2.6 g)

Sources & evidence

ORD record
ord-a41508f97fe44daa84694556a62f3dc7
Source dataset
uspto-grants-2001_09
Patent number
US06291503B1

Reaction notes

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