Stannous Chloride → Ethyl 3-(3-aminophenyl)-3-(2,4-dichlorophenylacetylamino)-propionate

HRID 1596571Notes

Reaction equation

HRID 1596571 reaction equation
[Cl:1][CH:2]([C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=1)[C:3]([NH:5][CH:6]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-])=O)[CH:14]=1)[CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:4].[Sn](Cl)Cl>>[NH2:19][C:15]1[CH:14]=[C:13]([CH:6]([NH:5][C:3](=[O:4])[CH:2]([C:22]2[CH:23]=[CH:24][C:25]([Cl:28])=[CH:26][CH:27]=2)[Cl:1])[CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 24479Stannous ChlorideHCID 70018101Ethyl 3-(2,4-dichlorophenylacetylamino)-3-(3-nitrophenyl)-propionate

Product 1

HCID 70018029Ethyl 3-(3-aminophenyl)-3-(2,4-dichlorophenylacetylamino)-propionate

Procedure

Corresponding to Example 3b, 3.1 g of (5a) were reduced using tin-(II) dichloride. A white solid was obtained (yield: 0.9 g).

Workup

  1. customA white solid was obtained (yield: 0.9 g)

Sources & evidence

ORD record
ord-88d310e359ee4eaf9482a1fd80ca89cf
Source dataset
uspto-grants-2001_09
Patent number
US06291503B1

Reaction notes

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