3-Nitrobenzenesulfonyl chloride → Ethyl 3-(3-[3-nitrophenylsulphonylamino]-phenyl)-3-(2-phenylbutyrylamino)propionate
Reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:15][C:16](=[O:26])[CH:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:18][CH3:19])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[CH:6][CH:7]=1.[N+:27]([C:30]1[CH:31]=[C:32]([S:36](Cl)(=[O:38])=[O:37])[CH:33]=[CH:34][CH:35]=1)([O-:29])=[O:28]>>[N+:27]([C:30]1[CH:31]=[C:32]([S:36]([NH:1][C:2]2[CH:3]=[C:4]([CH:8]([NH:15][C:16](=[O:26])[CH:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:18][CH3:19])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[CH:6][CH:7]=2)(=[O:38])=[O:37])[CH:33]=[CH:34][CH:35]=1)([O-:29])=[O:28]Participants
3
Procedure
Corresponding to Example 3c, 3.9 g of (7b) were reacted with 3-nitrophenylsulphonyl chloride. A solid was obtained (yield: 5.0 g).
Workup
- customA solid was obtained (yield: 5.0 g)
Sources & evidence
- ORD record
- ord-a58a8b00f0e342aababcf65b657db27d
- Source dataset
- uspto-grants-2001_09
- Patent number
- US06291503B1
Reaction notes
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