HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalic Anhydride → HCID 21702120, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalic Anhydride | HCID 6811 | — |
| Reactant | 1-Phenethylamine | HCID 7408 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Propionyl chloride | HCID 62324 | — |
| Reactant | Potassium thiocyanate | HCID 516872 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 21702120 | HCID 21702120 | — |
Reaction Steps
Reagents: (a) α-methyl-benzylamine, cat. p-TosOH, toluene, Δ; (b) H2, Pd/C 10%, MeOH; (c) Phtalic anhydride, HOAc, Δ; (d) propionylchloride, Et3N, CH2Cl2; (e) propionylchloride, Et3N, CH2Cl2; (f) H2NNH2.H2O, EtOH, Δ; (g) KSCN, Br2, HOAc, r.t.; (h) separation of diastereomers and possible regioisomers; (i) LiAlH4, Et2O, r.t.; (j) HCO2NH4, Pd/C 10%, MeOH, A; (k) propionylchloride, Et3N, CH2Cl2; (l) BH3in THF, Et2O, Δ.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06291494B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-0859a801f2f8418c99f3ab0370c8147d |
| Source note | uspto-grants-2001_09 |