Potassium Hydroxide → HCID 178525928, compound

Participants

Reaction Steps

To a stirred solution of the compound prepared in Example 71, above (1.03 g, 3.32 mmol), in a THF/MeOH (5 ml/5 ml) solution was added dropwise KOH (0.285 g, 4.32 mmol) in H2O (7 ml). After stirring overnight, the volatiles were removed in vacuo, an Et2O/H2O (40 ml/30 ml) mixture was added, the aqueous layer was separated and acidified with 10% aqueous HCl and the whole was extracted with ethyl acetate (2×50 ml), washed with water and brine, then dried over MgSO4 and evaporated in vacuo. The resulting solid was triturated with an Et2O/n-hexane mixture to afford 0.74 g of desired product as a colorless solid, m.p. 137-139° C. (dec.).

Provenance & Evidence