Chloroacetyl chloride → HCID 21938676, compound

Participants

Reaction Steps

A mixture of 230 g (0.9 mol) N-(2′-chloro-4′,6′-difluorophenyl)-4-methylaniline and 325 ml (4.06 mol) of chloroacetyl chloride is heated under a nitrogen atmosphere for one hour at 50°. The solvent is evaporated under reduced pressure to give an oil to which 200 ml of chlorobenzene is added. The solvent is evaporated under reduced pressure to completely remove the chloroacetyl chloride, giving N-(2′-chloro4′,6′-difluorophenyl)-N-chloroacetyl-4-methylaniline as an oil.

Provenance & Evidence