HCID 69843415, compound → HCID 69842868, compound

HRID 1596676Notes

Reaction equation

HRID 1596676 reaction equation
Cl.[NH2:2][N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH2:15][C:14]3([CH2:20][CH2:19][N:18]([CH2:21][CH2:22][CH2:23][C:24]([O:26]CC)=[O:25])[CH2:17][CH2:16]3)[O:13][N:12]=2)=[CH:7][CH:6]=1>C(O)C.[OH-].[Na+]>[NH2:2][N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH2:15][C:14]3([CH2:16][CH2:17][N:18]([CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])[CH2:19][CH2:20]3)[O:13][N:12]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 1

HCID 69843415HCID 69843415, compound

Product 1

HCID 69842868HCID 69842868, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

0.28 g (0.685 mmol) of the ethyl ester from Example 7 were hydrolized in a mixture of 4 ml ethanol and 0.9 ml 2 N aqueous sodium hydroxide solution according to the procedure from Example 6. The title acid crystallized from water/ethanol 1:2, and it was filtered and dried in vacuo.

Workup

  1. customThe title acid crystallized from water/ethanol 1:2, and it
  2. filtrationwas filtered
  3. customdried in vacuo

Sources & evidence

ORD record
ord-85579f1d5e944b289a252f5fa386f438
Source dataset
uspto-grants-2001_09
Patent number
US06291469B1

Reaction notes

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