Acetic Acid → HCID 69843158, compound

HRID 1596681Notes

Reaction equation

HRID 1596681 reaction equation
Cl.[NH2:2][N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH2:15][C:14]3([CH2:20][CH2:19][N:18]([C:21](=[O:30])[CH2:22][CH2:23][CH2:24][C:25]([O:27]CC)=[O:26])[CH2:17][CH2:16]3)[O:13][N:12]=2)=[CH:7][CH:6]=1.[OH-].[Na+].C(O)(=O)C>C(O)C>[NH2:2][N:3]=[CH:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH2:15][C:14]3([CH2:20][CH2:19][N:18]([C:21](=[O:30])[CH2:22][CH2:23][CH2:24][C:25]([OH:27])=[O:26])[CH2:17][CH2:16]3)[O:13][N:12]=2)=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 69843013HCID 69843013, compound

Product 1

HCID 69843158HCID 69843158, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.34 g (0.78 mmol) of the ethyl ester from Example 16 were dissolved in 5 ml ethanol, and after addition of 1 ml 2 N aqueous sodium hydroxide solution the mixture was stirred over night. It was brought to pH 5 with diluted acetic acid, stirred for 30 min, and the title acid was filtered with suction, washed with water and ethanol, successively, and dried in vacuo at 50° C.

Workup

  1. stirringstirred for 30 min
  2. filtrationthe title acid was filtered with suction
  3. washwashed with water and ethanol
  4. customsuccessively, and dried in vacuo at 50° C.

Sources & evidence

ORD record
ord-6c8f7a3c74ad48bb978b83c8af86152f
Source dataset
uspto-grants-2001_09
Patent number
US06291469B1

Reaction notes

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