Acetic Acid → HCID 69842471, compound

HRID 1596682Notes

Reaction equation

HRID 1596682 reaction equation
Cl.[NH2:2][N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH2:15][C:14]3([CH2:20][CH2:19][N:18]([CH2:21][CH2:22][CH2:23][CH2:24][C:25]([O:27]CC)=[O:26])[CH2:17][CH2:16]3)[O:13][N:12]=2)=[CH:7][CH:6]=1.[OH-].[Na+].C(O)(=O)C>C(O)C>[NH2:2][N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH2:15][C:14]3([CH2:16][CH2:17][N:18]([CH2:21][CH2:22][CH2:23][CH2:24][C:25]([OH:27])=[O:26])[CH2:19][CH2:20]3)[O:13][N:12]=2)=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium Hydroxide2×HCID 69842851HCID 69842851, compound

Product 1

HCID 69842471HCID 69842471, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 0.4 g (0.946 mmol) of the ester from Example 18 in 6 ml ethanol were added 1.2 ml 2 N aqueous sodium hydroxide solution. The mixture was stirred at room temperature over night, and stirring was continued for another 30 min after addition of another 0.2 ml sodium hydroxide. It was brought to pH 5 with diluted acetic acid, and the precipitate of the title compound was filtered with suction. After stirring with a small amount of water for 30 min, it was filtered again, washed with water and with ethanol, and dried in vacuo at 60° C.

Workup

  1. stirringstirring
  2. filtrationthe precipitate of the title compound was filtered with suction
  3. stirringAfter stirring with a small amount of water for 30 min
  4. filtrationit was filtered again
  5. washwashed with water and with ethanol
  6. customdried in vacuo at 60° C.

Sources & evidence

ORD record
ord-36bafcc0b2be40afb27d9c67c949d203
Source dataset
uspto-grants-2001_09
Patent number
US06291469B1

Reaction notes

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