Ethyl bromoacetate → Ethyl [5-acetyl-2-(2,6-difluorobenzyloxy)-phenoxy]-acetate

Beteiligte Stoffe

Reaktionsschritte

A mixture of 3′-hydroxy-4′-(2,6-difluorobenzyloxy)-acetophenone (15.0 g, 53.96 mmol), ethyl bromoacetate (7.2 mL, 64.75 mmo), and K2CO3 (14.9 g, 107.92 mmol) in acetone (350 mL) is refluxed 18 hours. After cooling, the mixture is filtered, and the filtrate is concentrated in vacuo. Recrystallizaton from EtOAc yields ethyl [5-acetyl-2-(2,6-difluorobenzyloxy)-phenoxy]-acetate.

Herkunft & Nachweise