Potassium Carbonate → HCID 21702633, compound

Participants

Reaction Steps

A solution of methyl 5-bromosalicylate (12.70 g, 55 mmol), (1-bromoethyl)benzene (7.05 mL, 50 mmol), and K2CO3 (20.73 g, 150 mmol) in acetone (250 mL) is refluxed 18 hours. The mixture is then filtered and the filtrate is concentrated in vacuo. The residue is dissolved in EtOAc (250 mL) and then washed with 1 N NaOH (2×150 mL) and brine (1×100 mL), and dried over MgSO4. Concentration in vacuo yields methyl 5-bromo-2-(1-phenylethoxy)-benzoate.

Provenance & Evidence