Diethylamine → HCID 86757416, compound

Participants

Reaction Steps

To a solution of methyl (E)-5-(2-chlorocarbonyl-1-methylvinyl)-2-(1-phenylethoxy)-benzoate (1.0 g, 2.79 mmol)in THF (50 mL) is added diethylamine (1.16 mL, 11.8 mmol), and the mixture is stirred at room temperature for 3 hours, after which time THF is removed in vacuo, and the residue is lssoved in CH2Cl2 (75 mL) and then washed with 1 N HCl (2×100 mL) and brine (1×50 mL), and dried over MgSO4. Chromatography (silica, 2:1 hexane/EtOAc) yields methyl (E)-5-(2-diethylcarbamoyl-1-methylvinyl)-2-(1-phenylethoxy)-benzoate.

Provenance & Evidence