2-Bromopropionic acid → HCID 15335226, compound

HRID 1596759Notes

Reaction equation

HRID 1596759 reaction equation
[CH3:1][C:2]1[C:7](=[S:8])[CH2:6][CH:5]=[CH:4][C:3]=1[C:9]([O:11][CH3:12])=[O:10].[OH-].[Na+].Br[CH:16]([CH3:20])[C:17]([OH:19])=[O:18]>O>[C:17]([CH2:16][CH2:20][S:8][C:7]1[C:2]([CH3:1])=[C:3]([CH:4]=[CH:5][CH:6]=1)[C:9]([O:11][CH3:12])=[O:10])([OH:19])=[O:18]

Participants

5

Reactant 3

HCID 117292-Bromopropionic acidHCID 14798Sodium HydroxideHCID 18432362HCID 18432362, compound

Product 1

HCID 15335226HCID 15335226, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

70 g (0.38 mol) of methyl 3-thio-2-methylbenzoate are dissolved in 400 ml of water and refluxed for 7 hours together with 30.8 g (0.77 mol) of sodium hydroxide solution and 58.8 g (0.45 mol) of bromopropionic acid. After cooling, the aqueous phase is washed using methyl tert-butyl ether. The aqueous phase is subsequently acidified using 2N HCl, the precipitate which has formed is filtered off with suction and washed with water, and the product is dried.

Workup

  1. temperatureAfter cooling
  2. washthe aqueous phase is washed
  3. customthe precipitate which has formed
  4. filtrationis filtered off with suction
  5. washwashed with water
  6. customthe product is dried

Sources & evidence

ORD record
ord-6271e347a77e44f5a8d3685be1af1bb1
Source dataset
uspto-grants-2001_09
Patent number
US06291682B1

Reaction notes

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