反应详情

13.8 g (0.058 mol) of methyl 4-hydroxy-8-methylthiochromane-7-carboxylate are heated below boiling point for 4 hours in 60 ml of ethanol with 1 g of sulfuric acid added. The solvent is then distilled off and the residue is taken up in water. The aqueous phase is extracted using ethyl acetate. The organic phase is washed using sodium hydrogen carbonate solution, dried and concentrated. The product is purified by chromatography.

1. customfor 4 hours
2. additionadded
3. distillationThe solvent is then distilled off
4. extractionThe aqueous phase is extracted
5. washThe organic phase is washed
6. customdried
7. concentrationconcentrated
8. customThe product is purified by chromatography