Acetic Acid → 8-Methyl-4-ethoxy-1,1-dioxothiochroman-7-carboxylic acid

Participants

Reaction Steps

8.4 g (0.033 mol) of 4-ethoxy-8-methylthiochromane-7-carboxylic acid are introduced into 60 ml of acetic acid. one spatula-tip full of sodium tungstate is added. 7.9 g (0.07 mol) of 30% strength hydrogen peroxide solution are slowly added dropwise at 50° C. Stirring is continued for 2 hours. The reaction batch is then poured into water and the aqueous phase is extracted using ethyl acetate. The organic phase is washed using bisulfite solution and then dried and concentrated.

Provenance & Evidence