HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 11189678, compound → HCID 11221557, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 11189678 | HCID 11189678 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 11221557 | HCID 11221557 | 85% |
Reaction Steps
A mixture of [3-(5-fluoro1H-indol-3-yl)-propyl]-[2-(2-methoxy-phenoxy) ethyl]-benzylamine (0.94 g, 2.2 mol) and 10lo palladium on carbon (250 mg) in ethanol was hydrogenated for 20 hours. The catalyst was filtered off and the solvent was removed under vacuum. Chromatography (10% methanol-methylene chloride) afforded 0.63 g (85%) of product as an off-white solid: mp 125-126° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06291683B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-99c4f38c82844dbaba1af20dd980fe6c |
| Source note | uspto-grants-2001_09 |