4-(2-chloroethoxy)-1H-indole → HCID 21703085, compound

HRID 1596785Notes

Reaction equation

HRID 1596785 reaction equation
[NH:1]1[C:9]2[C:4](=[C:5]([O:10][CH2:11][CH2:12]Cl)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[NH:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[C:15]1C(C)CCN>>[NH:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([CH:4]([CH3:5])[CH2:3][CH2:2][NH:1][CH2:12][CH2:11][O:10][C:5]2[CH:6]=[CH:7][CH:8]=[C:9]3[C:4]=2[CH:3]=[CH:2][NH:1]3)=[CH:15]1

Participants

3

Reactant 2

HCID 106317214-(2-chloroethoxy)-1H-indoleHCID 702033103-(1H-indol-2-yl)butan-1-amine

Product 1

HCID 21703085HCID 21703085, compoundYield 43%

Procedure

This compound was prepared in the manner described above for Example 5 using 2-(1H-indol-4-yloxy)ethylchloride and 3-indolyl-butylamine in 43% yield as an off-white solid: mp 70-73° C.

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-770f3001b19945f48233d1bf186e8289
Source dataset
uspto-grants-2001_09
Patent number
US06291683B1

Reaction notes

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