3-(5-fluoro-1H-indol-3-yl)propan-1-amine → HCID 9862968, compound

HRID 1596792Notes

Reaction equation

HRID 1596792 reaction equation
[C:1]1([O:11][CH2:12][CH2:13]Cl)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.F[C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][CH:20]=[C:19]2[CH2:25][CH2:26][CH2:27][NH2:28]>>[NH:21]1[C:22]2[C:18](=[CH:17][CH:16]=[CH:24][CH:23]=2)[C:19]([CH2:25][CH2:26][CH2:27][NH:28][CH2:13][CH2:12][O:11][C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][CH:2]=2)=[CH:20]1

Participants

3

Reactant 2

HCID 39570663-(5-fluoro-1H-indol-3-yl)propan-1-amineHCID 111833591-(2-chloroethoxy)naphthalene

Product 1

HCID 9862968HCID 9862968, compoundYield 85%

Procedure

This compound was prepared in the manner described above for Example 13 by replacing 2-(indan-4-yloxy)-ethylchloride with 2-(napthalen-1 -yloxy)-ethylchloride (0.6 g, 2.8 mmol), and 3-(5-fluoro-1H-indol-3-yl)-propylamine with 3-(1H-indol-3-yl)-propylarmine (1.35 g, 7.2 mmol) in 85% yield (1.42 g) as a yellow solid: mp 119-120° C.

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-7e102831a9d54f918ff0e69077253579
Source dataset
uspto-grants-2001_09
Patent number
US06291683B1

Reaction notes

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