Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethylphosphite | HCID 3780918 | — |
| Reactant | 4-(Bromomethyl)-1-fluoro-2-phenoxybenzene | HCID 12922714 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Tetrahydrofuran | HCID 8028 | 98% |
| Product | Phosphonic acid, [(4-fluoro-3-phenoxyphenyl)methyl]-, diethyl ester | HCID 11279166 | — |
Reaction Steps
A mixture of diethylphosphite (6.9 g, 0.05 mol) in tetrahydrofuran is cooled to 10° C., treated portionwise with sodium t-butoxide (4.9 g, 0.05 mol) while maintaining the reaction mixture temperature below about 20° C., stirred at room temperature for 5 minutes, cooled, and treated dropwise with 4-fluoro-3-phenoxybenzyl bromide (14.05 g, 0.05 mol) at about 10-15° C. to give a solution of the title product in tetrahydrofuran (98% yield by gas chromatography).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06291721B1 |
|---|
| Source dataset | uspto-grants-2001_09 |
|---|
| ORD ID | ord-15ba6dbb694244ddb3175ac9f194cd25 |
|---|
| Source note | uspto-grants-2001_09 |
|---|
