HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1597151Generated: October 31, 2026
Hydrochloric Acid → 5-Chloro-6-(3-nitro-1,2,4-triazol-1-ylmethyl)uracil
https://huagongshe.com/reaction/1597151
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-Chloro-6-(chloromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 4171056 | — |
| Reactant | HCID 178526901 | HCID 178526901 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 5-Chloro-6-(3-nitro-1,2,4-triazol-1-ylmethyl)uracil | HCID 21699314 | 73% |
Reaction Steps
To a solution of 0.88 g of 3-nitro-1,2,4-triazole in a 1 N aqueous solution of KOH (10 ml), 0.50 g of 5-chloro-6-chloromethyluracil was added, followed by heating at 80° C. for 2.5 hours under stirring. The reaction mixture was neutralized with 6 N hydrochloric acid. A precipitate was collected by filtration and then washed with water and methanol, whereby 510 mg of the title compound were obtained (yield: 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06294535B1 |
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| Source dataset | uspto-grants-2001_09 |
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| ORD ID | ord-8aad7676f86b48b98afd9229fada560c |
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| Source note | uspto-grants-2001_09 |
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