HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-fluorobenzonitrile → 2-Chloro-6-methoxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-fluorobenzonitrile | HCID 69587 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Chloro-6-methoxybenzonitrile | HCID 81055 | 98.5% |
Reaction Steps
2-Chloro-6-fluorobenzonitrile (Aldrich, 5.0 g, 32.1 mmol) was dissolved in MeOH (100 mL), NaOMe (7.4 mL of 25% wt. solution, 32.1 mmol) and refluxed 18 h. The mixture was concentrated poured into EtOAc/H2O and extracted with EtOAc to give the title compound (5.3 g, 59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294531B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-699121cca38b40abb0b9e82bd898b154 |
| Source note | uspto-grants-2001_09 |