HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 21699153, compound → HCID 22461667, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 21699153 | HCID 21699153 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22461667 | HCID 22461667 | 96.5% |
Reaction Steps
A solution of 2-carboxymethyl-5-methoxy-phenyl-oxy-(3-nitrobenzene) (57 g, 0.187 mol) and 10% Pd/C (11 g) was hydrogenated in MeOH (1000 mL) at 50 psi for 2 h. The solution was filtered through Celite® and the filtrate was concentrated. Flash chromatography (silica gel, 20% EtOAc/Hexane) yielded the title compound (49.3 g, 96%): MS (ES) m/e 274.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294531B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-430d2745c17140988b0d18fe68961aa3 |
| Source note | uspto-grants-2001_09 |