Water → HCID 15538683, compound

Participants

Reaction Steps

3-[7-Fluoro-5-nitro-2H-1,4-benzoxazine-3(4H)-on-6-yl]-6-trifluoromethyl-2,4-(1H, 3H)-pyrimidinedione (1.0 g) was dissolved in DMF (20 ml) containing potassium carbonate (1.0 g) and iodomethane (0.5 ml). The mixture was stirred for 2 hr and then water (30 ml) and ethyl acetate (40 ml) were added. The organic phase was washed with water (15 ml×2) and brine (15 ml), then dried over sodium sulfate. Filtration and evaporation gave the title compound (0.9 g).

Provenance & Evidence