HCID 15538683, compound → HCID 15538684, compound

Participants

Reaction Steps

3-[7-Fluoro-4-methyl-5-nitro-2H-1,4-benzoxazine-3(4H)-on-6-yl]-1-methyl-6-trifluoromethyl-2,4-(1H, 3H)-pyrimidinedione (1.45 g) was dissolved in acetic acid (80 ml) containing iron powder (1.16 g). The mixture was stirred for 3 days under nitrogen atmosphere. After filtration, water (100 ml) and ethyl acetate (150 ml) were added to the filtrate, the organic phase was washed with water (30 ml×3) and brine (30 ml), dried over sodium sulfate. After filtration and evaporation, the residue was purified by silica gel column (hexane to 40% ethyl acetate) to afford the title compound (1.1 g).

Provenance & Evidence