Water → HCID 23502535, compound

Participants

Reaction Steps

3-[5-Amino-7-fluoro-2H-1,4-benzoxazine-3(4H)-on-6-yl]-6-trifluoromethyl-2,4-(1H, 3H)-pyrimidinedione (4.0 g) was dissolved in DMF (200 ml) containing potassium carbonate (5 g) and iodomethane (10 ml). After stirring for 2 hr, water (150 ml) and ethyl acetate (200 ml) were added. The organic phase was washed with water (50 ml×3) and brine (50 ml), dried over sodium sulfate. After filtration and evaporation, the residue was recrystallized from methylene chloride and hexane to afford the title compound (3.3 g).

Provenance & Evidence