HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → HCID 21698918, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 2-(7-Fluoro-3-oxo-4H-1,4-benzoxazin-6-yl)-4,5,6,7-tetrahydroisoindole-1,3-dione | HCID 13772185 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 21698918 | HCID 21698918 | — |
Reaction Steps
2-[7-Fluoro-2H-1,4-benzoxazine-3(4H)-on-6-yl]-4,5,6,7-tetrahydro-2H-isoindole-1,3-dione (1.0 g) was stirred in acetic acid (20 ml) and fuming nitric acid (8 ml) was slowly added. Solution was stirred at ambient temperature for 1 hr and the clear solution was added to ice-water. Light yellow precipitate was separated by filtration to afford the title compound (0.95 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294503B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-0908b008f6184d7999c0f8e1446dad34 |
| Source note | uspto-grants-2001_09 |