4-(Benzyloxy)-5-methoxy-2-nitrobenzamide → HCID 21699258, compound

Participants

Reaction Steps

4-Benzyloxy-5-methoxy-2-nitrobenzamide (26 g, 91 mmol), (J. Med. Chem. 1977, vol 20, 146-149), was dissolved in TFA and heated at reflux for 2 hours. After cooling the TFA was removed by evaporation and the residue was stirred with 2M sodium hydroxide and insoluble material was removed by filtration. The red aqueous solution was acified to pHl with concentrated hydrochloric acid and allowed to cool back to ambient temperature before collecting the product by filtration. The obtained solid was washed with water and ether and dried in a vacuum oven at 60° C. to give 4-hydroxy-5-methoxy-2-nitrobenzamide (11.04 g, 62%).

Provenance & Evidence