HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 1-Benzyl-4-piperidone | HCID 19220 | — |
| Reactant | Piperidine, hydrochloride (1:1) | HCID 2723721 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile | HCID 2733434 | 95.4% |
Reaction Steps
12.16 g of piperidine hydrochloride and 18.9 g of 1-benzylpiperid-4-one are dissolved in 50 ml of an MeOH/H20 mixture (50/50; v/v). 5.3 g of NaCN dissolved in 20 ml of water are added dropwise. After stirring for 48 hours, the precipitate formed is filtered, rinsed with water and dried to give 27 g of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294537B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-c96c12078ae548d29d26a151cbb5c173 |
| Source note | uspto-grants-2001_09 |