Trityl chloride → HCID 21699548, compound

Participants

Reaction Steps

A mixture of 0.565 g of 4-(cyclopropylcarbonylamino)-4-phenylpiperidine hydrochloride in 50 ml of DCM is cooled to +5° C., 0.565 g of trityl chloride is added followed by 0.7 ml of triethylamine and the mixture is kept stirring while allowing the temperature to rise to RT. The reaction mixture is washed with water, the organic phase dried over MgSO4 and the solvent evaporated under vacuum. 1 g of the expected product is obtained after crystallization from ether.

Provenance & Evidence