Methyl 4-cyano-4-(3,4-dichlorophenyl)heptanedioate → Methyl 3-[5-(3,4-dichlorophenyl)-2-oxopiperid-5-yl]propionate

Participants

Reaction Steps

40 g of the compound prepared in stage A are dissolved in 500 ml of 2-methoxyethanol, 2 g of Raney® nickel are added and the mixture is hydrogenated at 40° C. at atmospheric pressure for 3 days. The mixture is filtered, evaporated and the expected product is obtained in the form of an oil (39 g).

Provenance & Evidence