反应详情

2-Benzyl-1,2,3,4-tetrahydro-benzo[b][1,6]-naphthyridine (4.4 g, 16.04 mmol) was dissolved in methanol (88 ml), followed by adding thereto acetic acid (1.84 ml, 32.08 mmol) and palladium-carbon (440 mg), and catalytic reduction was carried out overnight at 50° C. The catalyst was filtered off and the filtrate was neutralized with potassium carbonate and filtered. The organic layer thus obtained was concentrated under reduced pressure and the residue was purified by a silica gel column chromatography (methylene chloride/methanol=30/1 to 10/1) to obtain the desired compound (1.1 g, 37.2%) as a brown solid.

1. additionby adding
2. filtrationThe catalyst was filtered off
3. filtrationfiltered
4. customThe organic layer thus obtained
5. concentrationwas concentrated under reduced pressure
6. customthe residue was purified by a silica gel column chromatography (methylene chloride/methanol=30/1 to 10/1)