1,4-Dioxane hydrochloride → HCID 21699683, compound

HRID 1597280Notes

Reaction equation

HRID 1597280 reaction equation
[NH2:1][C:2]1[C:11]2[CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7][C:6]=2[N:5]=[C:4]2[CH:19]=[CH:20][CH:21]=[CH:22][C:3]=12.[ClH:23].O1CCOCC1>O1CCOCC1>[ClH:23].[ClH:23].[ClH:23].[NH2:1][C:2]1[C:11]2[CH2:10][NH:9][CH2:8][CH2:7][C:6]=2[N:5]=[C:4]2[CH:19]=[CH:20][CH:21]=[CH:22][C:3]=12

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21699658HCID 21699658, compound

Product 1

HCID 21699683HCID 21699683, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

10-Amino-2-t-butoxycarbonyl-1,2,3,4-tetrahydro-benzo[b][1,6]-naphthyridine (0.538 g, 1.80 mmol) was suspended in dioxane (3 ml), followed by adding thereto 4N-hydrogen chloride/dioxane (9 ml) under ice-cooling, and the resulting mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated to obtain the desired compound (0.585 g, quant.).

Workup

  1. additionby adding
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-c8827138c6d14008ba41974119b59de2
Source dataset
uspto-grants-2001_09
Patent number
US06294547B1

Reaction notes

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