1,4-Dioxane hydrochloride → HCID 21699689, compound

HRID 1597284Notes

Reaction equation

HRID 1597284 reaction equation
[CH3:1][C:2]([NH:4][C:5]1[C:14]2[CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10][C:9]=2[N:8]=[C:7]2[CH:22]=[CH:23][CH:24]=[CH:25][C:6]=12)=[O:3].[ClH:26].O1CCOCC1>O1CCOCC1.CO>[ClH:26].[ClH:26].[C:2]([NH:4][C:5]1[C:14]2[CH2:13][NH:12][CH2:11][CH2:10][C:9]=2[N:8]=[C:7]2[CH:22]=[CH:23][CH:24]=[CH:25][C:6]=12)(=[O:3])[CH3:1]

Participants

5

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21699665HCID 21699665, compound

Product 1

HCID 21699689HCID 21699689, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

10-Methylcarbonylamino-2-t-butoxycarbonyl-1,2,3,4-tetrahydro-benzo[b][1,6]-naphthyridine (0.5 g, 1.47 mmol) was suspended in a mixture of dioxane (4.5 ml) and methanol (1 ml), followed by adding thereto 4N-hydrogen chloride/dioxane (7.35 ml) under ice-cooling, and the resulting mixture was stirred at room temperature for 1.5 hours. The reaction mixture was concentrated to obtain the desired compound (0.369 g, quant.).

Workup

  1. additionby adding
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-16f60efa3ba746fda022b8a00e257d41
Source dataset
uspto-grants-2001_09
Patent number
US06294547B1

Reaction notes

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