Ammonia → HCID 8966164, compound

HRID 1597285Notes

Reaction equation

HRID 1597285 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[NH2:15][C:16]1[CH:29]=[CH:28][CH:27]=[CH:26][C:17]=1[C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=O.S(=O)(=O)(O)O.N>C(O)(=O)C>[CH2:6]([N:8]1[CH2:9][CH2:10][C:11]2[N:15]=[C:16]3[CH:29]=[CH:28][CH:27]=[CH:26][C:17]3=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:12]=2[CH2:13]1)[C:16]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:17]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 1118Sulfuric AcidHCID 760802-AminobenzophenoneHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 8966164HCID 8966164, compoundYield 145.7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1-t-Butoxycarbonyl-4-piperidone (1.93 g, 10.2 mmol) and 2-aminobenzophenone (2.01 g, 10.2 mmol) were suspended in acetic acid (10 ml), followed by adding thereto sulfuric acid (0.1 ml), and the reaction was carried out at 120° C. for 1 hour. The reaction mixture was poured into cold aqueous ammonia, and the crystals precipitated were washed with water and recrystallized from ethanol to obtain the desired compound (2.60 g, 7.43 mmol).

Workup

  1. additionby adding
  2. customthe crystals precipitated
  3. washwere washed with water
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-c41005ad316540c6b1eb6214c0c00328
Source dataset
uspto-grants-2001_09
Patent number
US06294547B1

Reaction notes

Loading…