Dimethylcarbamoyl Chloride → HCID 9955502, compound

Participants

Reaction Steps

To a solution of 4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide (610 mg) in methylene chloride (30 ml) is added triethylamine (0.22 ml), and further thereto is added dimethylcarbamoyl chloride (0.15 ml) under ice-cooling. The mixture is stirred at room temperature for 5 hours. The reaction mixture is washed with water and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and the solvent is evaporated under reduced pressure. The residue is purified by basic silica gel column chromatography (eluent; chloroform) to give the desired compound (720 mg) as white amorphous.

Provenance & Evidence