HCID 10679101, compound → HCID 15463736, compound

Participants

Reaction Steps

To a solution of chloromethyl N-phenylcarbamate (220 mg), which is prepared by the method disclosed in Synth. Commun., 1996, 26, 4253, in ethanol (20 ml) is added dropwise a solution of 4-amino-5-chloro-2-methoxy-N-[1-(4-piperidinylmethyl)-4-piperidinyl]benzamide (910 mg) in ethanol (10 ml) at room temperature, and the mixture is stirred at room temperature for 7 hours. The mixture is concentrated to dryness under reduced pressure, and the residue is dissolved in chloroform, washed with water and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and the solvent is evaporated under reduced pressure. The residue is purified by silica gel column chromatography (eluent; chloroform:methanol=30:1) to give the desired compound (480 mg) as white amorphous.

Provenance & Evidence