反应详情

To 3-Quinolin-4-yl-propane-1,2-diamine (0.080 g, 3.98 mmol) in 5 ml of dry dichloromethane, formimidic acid ethyl ester hydrochloride (0.174 g, 7.36 mmol) (Ohme, R. et al. Angew.Chem.Int.Engl.Ed. 1967, 6, 90.) was added. The reaction mixture was stirred overnight at room temperature. Aqueous ammonia (2 ml) was added to he reaction mixture and was partitioned between EtOAc (2×5 ml) and water. The organic layer was dried, filtered and concentrated to give 0.084 g (110%) of the product as a syrup.

1. customwas partitioned between EtOAc (2×5 ml) and water
2. customThe organic layer was dried
3. filtrationfiltered
4. concentrationconcentrated