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To 1-Quinolin-4-yl-ethanol (1.4 g, 8.09 mmol) in 15 ml chloroform, thiony-chloride (1.8 ml, 20.2 mmol) was added dropwise over a five minute period at room temperature. Stirring was continued for 30 minutes after which the reaction mixture was cooled to 0° C. and quenched carefully by the addition of saturated aqueous NaHCO3 (20 ml). The chloroform layer was dried over sodium sulfate, filtered and concentrated. Column purification (hexane:ethyl acetate; 1.5:3.5) gave 1.54 g (100%) of the product as a syrup which was used as such for the subsequent step.

1. customquenched carefully by the addition of saturated aqueous NaHCO3 (20 ml)
2. dry with materialThe chloroform layer was dried over sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. customColumn purification (hexane:ethyl acetate; 1.5:3.5)