HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → 1-{3-[(4'-Fluoro[1,1'-biphenyl]-4-yl)sulfonyl]-2-hydroxypropyl}-4,4-dimethyl-2,6-piperidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 4,4-Dimethylpiperidine-2,6-dione | HCID 14292 | — |
| Reactant | 4-(4'-Fluorophenyl)-phenyl methyl sulfone | HCID 16086864 | — |
| Product | 1-{3-[(4'-Fluoro[1,1'-biphenyl]-4-yl)sulfonyl]-2-hydroxypropyl}-4,4-dimethyl-2,6-piperidinedione | HCID 21700065 | — |
Reaction Steps
Reaction of 4-(4′-fluorophenyl)-phenyl methyl sulfone with ethyl 3,3-dimethylglutarimideacetate (prepared from 3,3-Dimethylglutarimide and ethyl bromoacetate (as in Example 120A) following the procedures of Example 126A, followed by reduction as described in Example 126B afforded the two title products which were chromatographically separated to give the desired products.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294573B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-143eb7e78acf4da381a50e842631a733 |
| Source note | uspto-grants-2001_09 |